Quisinostat ( (JNJ-26481585) )

产品货号. M16360 CAS No. 875320-29-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Quisinostat
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Quisinostat (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11.
产品描述

Quisinostat (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. Phase 2.
同义词

(JNJ-26481585)
通路

Cell Cycle/DNA Damage
靶点

HDAC
受体

HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC8
研究领域

Cancer
适应症

——

CAS Number

875320-29-9
分子量

394.48
分子式

C21H26N6O2
纯度

>98%(HPLC)
溶解度

DMSO:79 mg/mL (200.26 mM); Ethanol:<1 mg/mL (<1 mM); Water:<1 mg/mL (<1 mM)
SMILES

O=C(C1=CN=C(N2CCC(CNCC3=CN(C)C4=C3C=CC=C4)CC2)N=C1)NO
化学全称

N-hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)methyl)piperidin-1-yl)pyrimidine-5-carboxamide

1.Arts J, et al. Clin Cancer Res, 2009, 15(22), 6841-685

计算器

产品手册

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